Question

What are the 2 basic type of communication within bcells

Answer 1

Macrophages work with helper T cells to initiate an immune response by activating B cells to produce plasma cells, which release antibodies that destroy the specific antigen. Macrophages present antigen fragments to helper T cells, which activate B cells, and that B cells produce plasma cells that release antibodies to destroy the antigen.

The control of B cell isotype switching and Ig secretion is dependent on soluble factors secreted by the activated T cell. Because cytokine secretion by the T cell is directed towards the contact site with the B cell. B cells can proliferate in a burst of more than one division, and these cells are susceptible to the effects of cytokines.

The B cell antigen receptor (BCR) is composed of membrane immunoglobulin (mIg) molecules and associated Ig?/Ig? (CD79a/CD79b) heterodimers (?/?). The mIg subunits bind antigen, resulting in receptor aggregation, while the ?/? subunits transduce signals to the cell interior. BCR aggregation rapidly activates the Src family kinases Lyn, Blk, and Fyn as well as the Syk and Btk tyrosine kinases. This initiates the formation of a ‘signalosome’ composed of the BCR, the aforementioned tyrosine kinases, adaptor proteins such as CD19 and BLNK, and signaling enzymes such as PLC?2, PI3K, and Vav. Signals emanating from the signalosome activate multiple signaling cascades that involve kinases, GTPases, and transcription factors. This results in changes in cell metabolism, gene expression, and cytoskeletal organization.

B lymphocytes also can bind antigen that is circulating in blood or lymph via the B-cell receptor complex (BCR).

The BCRs have associated molecules (Ig-alpha and Ig-beta) that can communicate between the surface receptor and the B lymphocyte cytoplasm and nucleus, so that antigen binding can signal the B cell to mature, become activated, and begin producing antibodies

They communicate by Direct Cellular Contact which is bidirectional