PLEASE ANSWER ALL PARTS FULLY! What is the difficulty with replicating the ends of linear chromosome—diagram...

PLEASE ANSWER ALL PARTS FULLY!

What is the difficulty with replicating the ends of linear chromosome—diagram the problem? How do telomeres and telomerase solve this problem-diagram this? How might this knowledge be useful in developing anti-cancer therapies?

Expert Solution

The ends of the DNA doesnt contain any coding sequences. So the problem is how the ends will get replicated without mRNA. If the ends are not replicated then ultimately after a certain time, the coding regions of DNA will get deleted . So it become essential to maintain the telomeres.
Telomerases are enzyme that has internal RNA and has reverse transcriptase activity,They function to replicate the telomeres with their internal RNA sequence.

Most of the human proliferative tissues and organs, including most somatic cells (even stem cells), exhibit progressive telomere shortening throughout life. Many studies has shown the relationship between telomere shortening and proliferative failure of human cells, that ultimately causes cancer (uncontrolled cell growth).

Most human cancers have short telomeres and express high levels of telomerase, while in most normal somatic tissues telomerase is absent.

Telomerase has been examined in many of studies as a potentially sensitive biomarker for screening, early detection of cancer, prognosis or in monitoring as an indication of future diseases. Cancer cells need a mechanism to maintain telomeres if these cells are going to divide indefinitely, and telomerase solves this problem. Anti-telomerase cancer therapy may prove useful in the prevention and detection of the cancers.

gladiator answered 1 year ago

9. The process of DNA replication creates a particular problem for replicating the ends of linear...

9. The process of DNA replication creates a particular problem for replicating the ends of linear chromosomes. a) Describe why the DNA replication machinery has difficulty replicating DNA ends. b) Telomerase has been identified as an enzyme that can reverse the outcome of end replication. Describe the near-universal mammalian chromosome telomere sequence and how telomerase solves the problem of end replication.

PLEASE ANSWER ALL PARTS FULLY! How was liquid hybridization used to compare species relatedness? What is...

PLEASE ANSWER ALL PARTS FULLY! How was liquid hybridization used to compare species relatedness? What is the purpose/significance of Driver versus Tracer DNA? What is Subtractive Hybridization, how/why would you use this technique? Compare Maxam-Gilbert and Sanger DNA sequencing methods. What are the more descriptive names for these techniques? How are the techniques similar? different? What reagents are used in each reaction? How are the results read? Do you get the sequence of the molecule you started with or the...

Please answer all the parts of this question Please answer all the parts of this question...

Please answer all the parts of this question Please answer all the parts of this question Question: a) Where is the flow accelerating in the control volume? b) Will the pressure be greater or less than hydrostatic in a region of accelerating flow? c) Is the hydrostatic estimate of force on the gate; larger, smaller, or the same, as that obtained from the Momentum Equation? Explain. d) Where does the change in flow momentum go in this control volume? Explain.

Please answer ALL parts of the question fully with detailed explanations. #Q5 a)Looking at the rat’s...

Please answer ALL parts of the question fully with detailed explanations. #Q5 a)Looking at the rat’s heart, how does the mammalian heart differs from those of reptiles? And from those of fishes? How similar is it to a bird’s heart? b)What advantage has the mammalian heart over the reptilian heart? Use diagrams if necessary. c) Compare & contrast both the skeletal systems and digestive systems individually in pigs, cats, and sheep. d) pig vs cat : What is the length...

PLEASE ANSWER ALL PARTS FULLY! How did the Meselson & Stahl’s experiment allow the investigators to...

PLEASE ANSWER ALL PARTS FULLY! How did the Meselson & Stahl’s experiment allow the investigators to distinguish between the 3 overall methods of DNA replication? What approaches were used in investigating the enzymology of DNA replication, remembering that studying an essential function presents a particular challenge?

Answer all parts as fully as you can, just as if it were a real exam...

Answer all parts as fully as you can, just as if it were a real exam (a) State the First Law of Thermodynamics (b) Explain the difference between heat and work (c) Explain why the heat capacity of a gas is different at constant pressure than at constant volume (d) Explain what is meant by the standard enthalpy of formation of a compound (e) Explain what is meant by the standard enthalpy of combustion of a compound (f) Use information...

Please answer all parts, it is not that lengthy. If you can't answer last parts, don't...

Please answer all parts, it is not that lengthy. If you can't answer last parts, don't attempt then . Leave for someone else A manufacturing process produces defective items 15% of the time. A random sample of 80 items is taken from the 3000 produced on a particular day, and each sampled item is tested to see if it is defective or not. In the context of this problem, identify each of the following: a. Population: b. Parameter of interest:...

Java Problem: Please answer both parts of the question fully: (a). Write Java code for a...

Java Problem: Please answer both parts of the question fully: (a). Write Java code for a method to test if a LinkedList<Long> has Long values that form a Fibonacci sequence from the beginning to the end and return true if it is and false otherwise. A sequence of values is Fibonnaci if every third value is equal to sum of the previous two. Eg., 3,4,7,11,18,29 is a Fibonacci sequence whereas 1,2,3,4 is not, because 2+3 is not equal to 4....

Please answer all parts of this question for both parts!! Prompt: In our study of the...

Please answer all parts of this question for both parts!! Prompt: In our study of the skeletal system this week it should be readily apparent to you how important synovial joints are in the normal function of the human body. This week you will pick two synovial joints to discuss. Pick one from each category below. For each selected joint you should provide the following information: the movements that are possible at that joint (use appropriate anatomical terminology), identification of...

Please answer all parts, thank you, and please type your answer and show all work including...

Please answer all parts, thank you, and please type your answer and show all work including excel formulas Exercise 15-15 The following data were taken from the balance sheet accounts of Shamrock Corporation on December 31, 2016. Current assets $554,000 Debt investments 596,000 Common stock (par value $10) 455,000 Paid-in capital in excess of par 148,000 Retained earnings 800,000 Prepare the required journal entries for the following unrelated items. (Credit account titles are automatically indented when amount is entered. Do...

Question