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What are the reactions that give rise to carbon dioxide transport as - HCO3, HHbCO2 (carbaminohemoglobin),...

What are the reactions that give rise to carbon dioxide transport as - HCO3, HHbCO2 (carbaminohemoglobin), and free CO2 . Show how these arise from CO2 and <carbonic anhydrase> and why these are really buffer equations. Imagine a defective carbonic anhydrase.

Solutions

Expert Solution

  • CO2 transport in plasma is similar to that occur in RBC
  • here physically dissolved form of transport - 5 to 7 %, bicarbonate form - 4% and as carbaminogroup - negligible
  • this act as a bicarbonate buffer
  • as base is HCO3- and acid is H2CO3(dissolved CO2)
  • acid base disturbance in the body is measured by calculating ratio of HCO3 : H2CO3
  • H2CO3 is a weak acid and its conjugate base is HCO3-
  • they react with strong acid and base as follows:
  • HCl + NaHCO3 H2CO3 +NaCl
  • NaOH + H2CO3 NaHCO3 + H2O
  • the pKa of bicarbonate buffer system is 6.1 so it act as optimum buffer at blood pH 7.4
  • also it is a most important buffer system as its constituents can independently i.e, CO2 by lungs and bicarbonate by kidney
  • defective carbonic anhyride impair body acid base balance

gladiator answered 2 years ago
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