In: Chemistry
Which of the following are needed for a ribosome to synthesize a polypeptide chain?
aminoacyl-tRNAs
RNA POLYMERASE
promoter
helicase
mRNA
ATP
Answer: mRNA & aminoacyl-tRNAs
mRNA functions: -messenger RNA
-copy of one gene, -made from a DNA template (transcription),
-template for making a protein (translation)
To synthesize poloypeptide (also called as protein), amino acids need to be assembled at the ribosome and to do this tRNA molecules charged with the correct amino acid are needed to bring the amino acid to the ribosome. Using the mRNA as a template, the ribosome traverses each codon (3 nucleotides) of the mRNA, pairing it with the appropriate amino acid provided by an aminoacyl-tRNA. The ribosome contains three RNA binding sites, designated A, P and E. The A site binds an aminoacyl-tRNA; the P site binds a peptidyl-tRNA (a tRNA bound to the peptide being synthesized); and the E site binds a free tRNA before it exits the ribosome.
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