How does glycogenesis in the liver differ from glycogenesis in muscle cells? In reference to the...

How does glycogenesis in the liver differ from glycogenesis in muscle cells?

In reference to the process. I know that the glucose is phosphorylated by different enzymes

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Expert Solution

Synthesis of glycogen from glucose is glycogenesis. It occurs in cytosol of muscles and in liver .

In liver, glycogenesis starts with phosphorylation of glucose by glucokinase enzyme.

In muscles , glycogenesis starts with phosphorylation of glucose by hexokinase enzyme.

Liver cannot utilise the phosphorylated form of glucose so it needs glucose 6 phosphatase to dephosphorylate glucose and transport glucose outside the cell .

Muscles can utilise the phosphorylated form of glucose so it doesn't need glucose 6 phosphatase. Since it lacks glucose 6 phosphatase , the phosphorylated glucose cannot be transported to the blood.so it can't be used to maintain the blood glucose levels .

Liver glycogen maintain normal blood sugar levels in the body .

Muscle glycogen provide energy for contraction of muscles.

Glycogen is present more in muscles than in liver.

gladiator answered 1 year ago

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