Question

How does glycogenesis in the liver differ from glycogenesis in muscle cells?

In reference to the process. I know that the glucose is phosphorylated by different enzymes

Answer 1

Synthesis of glycogen from glucose is glycogenesis. It occurs in cytosol of muscles and in liver .

In liver, glycogenesis starts with phosphorylation of glucose by glucokinase enzyme.

In muscles , glycogenesis starts with phosphorylation of glucose by hexokinase enzyme.

Liver cannot utilise the phosphorylated form of glucose so it needs glucose 6 phosphatase to dephosphorylate glucose and transport glucose outside the cell .

Muscles can utilise the phosphorylated form of glucose so it doesn't need glucose 6 phosphatase. Since it lacks glucose 6 phosphatase , the phosphorylated glucose cannot be transported to the blood.so it can't be used to maintain the blood glucose levels .

Liver glycogen maintain normal blood sugar levels in the body .

Muscle glycogen provide energy for contraction of muscles.

Glycogen is present more in muscles than in liver.