Explain step-by-step the transduction pathway of Acetylcholine in the heart.

Explain step-by-step the transduction pathway of Acetylcholine in the heart.

Expert Solution

Muscarinic acetylcholine receptor is the cholinergic receptor on heart. It is a type of GPCR receptor. When it is activated these will slow the rate of heart muscle contraction.

When ligand bind on to the receptor it release it G βγ subunit. This G βγ will directly activate K+ channel. The subsequent efflux of K+ from cytosol leads to the inside negative potential across plasma membrane. So the membrane is hyperpolarized. So heart muscle relaxation occur.

The Gἀ subunit when ligand bind (on to receptor) is inhibitory in nature. So the adenyl cyclase enzyme is not activated so decreased amount of adenylyl cyclase leads to decreased amount of cAMP. So subsequent effect also cancelled due to the inactivated state of PKA, and ca+ channels remains closed. All this events leads to the heart muscle relaxation.

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gladiator answered 1 year ago

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