Question

Signal Transduction:

A) Explain how growth factors, acting through the signal transduction pathway, regulate cell proliferation.  Names of specific proteins and their function must be given.

B) Give 2 specific examples of how an alteration in the signal transduction pathway can lead to cancer

Cell Cycle Regulation:

Describe the mechanism by which the cell cycle is regulated by mitogens. In your answer, be sure to include the following:

a) The phases of the cell cycle and protein whose concentrations vary during the cell cycle

b) The complexes formed by the proteins in (a) and the mechanisms by which they are regulated

c) The substrate of the complexes in (b) and its role in cell cycle control

d) Describe 2 ways in which the substrate in (c) can be inactivated to cause cancer

Answer 1

Receptor tyrosine kinase (RTK) signaling pathway is involved in the growth factor receptors mediated signaling.