In: Biology
GATA family of transcription factors are important regulators of cell identity. The family member GATA1 is required for the switch from an immature erythroid cell into a mature red blood cell. As part of this switch, GATA1 binds to the consensus DNA sequence GATAAA through interactions with the DNA major groove. One of the results is the massive upregulation of globin mRNA.
Design a set of experiments to demonstrate that GATA1 binds to GATAAA containing sequences and does so through major groove recognition/binding mechanisms.
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