Generally speaking, which of the following mutations would most severely affect the protein coded for by a gene?

a base substitution at the beginning of the gene
a base substitution at the end of the gene
a frameshift deletion at the beginning of the gene
a frameshift deletion at the end of the gene

Expert Solution

deleting one base pair yields the change in the amino acid coded for every codon following the deletion. deletion at the beginning of the gene will change more codons and eventually more amino acids.

a frameshift deletion at the beginning of the gene.

Dr. OWL answered 3 years ago

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