Question

1. In the CNS, morphine _______.

		inhibits GABAergic neurons in the VTA.
		decrease synthesis of dopamine
		inhibits emetic centers.
		prevents re-uptake of 5HT.
		All of the above
		A., B. and C.
		A., B, and D.
		B., C. and D
		None of the above

Answer 1

1. In the CNS, morphine _______.

		1. inhibits GABAergic neurons in the VTA.
		2.decrease synthesis of dopamine
		3. inhibits emetic centers.
		4.prevents re-uptake of 5HT.
		a) All of the above
		b) A., B. and C.
		c)A., B, and D.
		d) B., C. and D
		e) None of the above

- option a is incorrect as morphine activates the GABAergic neurons in the VTA, So, all the above are not correct.

- Option b, c and e are incorrect as the first statement is not correct.

- Option d is correct as statement 2, 3 and 4 are correct.

CORRECT STATEMENTS

Statement 2 morphine decreases the concentration of dopamine by reverse microdialysis.

Statement 3 morphine inhibits emesis centre by antagonising D2 receptors and D2 receptors are those which informs emesis centre about emetic agents.

Statement 4 morphine increases the tolerance of ant-nociceptors in the patient by re-uptake of 5HT.