Question

In: Nursing

In the CNS, morphine _______. inhibits GABAergic neurons in the VTA. decrease synthesis of dopamine inhibits...

  1. In the CNS, morphine _______.

inhibits GABAergic neurons in the VTA.

decrease synthesis of dopamine

inhibits emetic centers.

prevents re-uptake of 5HT.

All of the above

A., B. and C.

A., B, and D.

B., C. and D

None of the above

Solutions

Expert Solution

  1. In the CNS, morphine _______.

1. inhibits GABAergic neurons in the VTA.

2.decrease synthesis of dopamine

3. inhibits emetic centers.

4.prevents re-uptake of 5HT.

a) All of the above

b) A., B. and C.

c)A., B, and D.

d) B., C. and D

e) None of the above

- option a is incorrect as morphine activates the GABAergic neurons in the VTA, So, all the above are not correct.

- Option b, c and e are incorrect as the first statement is not correct.

- Option d is correct as statement 2, 3 and 4 are correct.

CORRECT STATEMENTS

Statement 2 morphine decreases the concentration of dopamine by reverse microdialysis.

Statement 3 morphine inhibits emesis centre by antagonising D2 receptors and D2 receptors are those which informs emesis centre about emetic agents.

Statement 4 morphine increases the tolerance of ant-nociceptors in the patient by re-uptake of 5HT.


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