Are the following statement regarding histone modifications true or false? Adding a methyl group to histones...

Are the following statement regarding histone modifications true or false?

Adding a methyl group to histones typically decreases gene activity. True / False

When chromatin is being condensed in preparation for cell division, HMTs act to modify histones in a way that tightens the DNA packaging. True / False

Adding an acetyl group to histones generally decreases gene activity. True / False

Once mitosis is completed, HDACs reducing the compactness of DNA packaging. True / False

Expert Solution

1. Adding a methyl group to histones typically decreases gene activity.

This is not always true. An addition of methyl group to histones may activate the gene activity or can repress it.

2. When chromatin is being condensed in preparation for cell division, HMTs act to modify histones in a way that tightens the DNA packaging. True

3. Adding an acetyl group to histones generally decreases gene activity.

False

Acetylation of histones activates the gene.

4. Once mitosis is completed, HDACs reducing the compactness of DNA packaging. False.

HDACs increase the compactness of DNA and do not allow the transcriptional assembly to bind at DNA sites and hence decreases gene activity.

gladiator answered 2 years ago

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