Question

Peptide antibiotics can be used to with cystic fibrosis patients, answer the following:

→ give the name of a peptide antibiotic that can be used to with cystic fibrosis patients:

→ Explain the therapeutic use of this peptide with cystic fibrosis patients?

Answer 1

Cathelicidin peptides Inhibit Multiple Antibiotic-Resistant Pathogens from patients with Cystic Fibrosis.

Cathelicidin peptides- These endogenous peptides contribute to innate immunity and are expressed in myeloid and epithelial cells. The cathelicidins of mammalian origin are synthesized in precursor form, requiring proteolytic processing to release the mature C-terminal antimicrobial peptide . They are typically linear, highly cationic, and salt insensitive and display broad-spectrum antimicrobial activities . The peptides kill bacteria by thinning and disrupting the bacterial membrane. Cathelicidins contribute to initial defense of the airway against inhaled pathogens. Recent studies have shown that the hormonally active form of vitamin D₃, 1,25- dihydroxyvitamin D₃ (1,25(OH)₂D₃) up-regulates AMP gene expression in several established cell lines. Furthermore, serum levels of vitamin D are often deficient in cystic fibrosis (CF) patients.