Question

What is the difference between a mut-driver gene and an epi-driver gene? and can driver genes have passenger gene mutations? explain please

Answer 1

Mut-driver gene

1.They are frequently cancer associated genes.

2.it may provide the identification Of contributions of different mutational signals.

3.it promote intragenic mutation contributes cancer

4.it provide contributions of mutagenesis and selection in carcinogenisis

  Epi-driver gene

  

1. They are abbrently expressed in the tumor.

2.They are not Frequently Mutated.

3.Change seen in the DNA methylation and chromatin Modification.

4.it persists the tumor cells to divide.

can driver genese have passenger mutation

Mutations that are provide selective growth and thus promote cancer development are termed driver mutation

Mutation that are not provide selective growth and thus promote cancer development are termed passenger mutation

The driver genes cannot have passenger mutation because passenger mutation has not conferred clonal growth Advantages and has not contributed to the cancer development