One of the strongest genetic linkages with lung cancer is an allele (version) of a gene...

One of the strongest genetic linkages with lung cancer is an allele (version) of a gene that produces a protein that binds to nicotine. Why might variation in this gene be associated with increased risk for lung cancer?

Expert Solution

Nicotine is an addictive substance that is found mainly in cigarette smoke. By itself, nicotine does not cause cancer. It simply excites the nervous system, and the person craves for even higher consumption of nicotine. Since cigarettes are one of the common sources of nicotine, people usually would resort to smoking cigarettes in order to fulfill their nicotine cravings.

The tar and other chemicals in cigarette smoke are responsible for cancer. These chemicals affect and damage DNA, including key genes that protect against cancer. Cigarette chemicals include benzene, polonium-210, benzo(a)pyrene and nitrosamines, which are known to damage DNA.

Since the allele is responsible for binding nicotine, it ensures that nicotine stays in the body for a longer amount of time and cannot be excreted or metabolized easily by the body. This means that the nicotine might not be available to the CNS as easily as before. Therefore, in order to increase the concentration of free nicotine in the system, the person would tend to smoke higher number of cigarettes. This would ultimately damage the system, and increase the chances of cancer.

gladiator answered 1 year ago

Gene therapy attempts to correct a genetic deficiency by inserting a normal version of the affected...

Gene therapy attempts to correct a genetic deficiency by inserting a normal version of the affected gene into the patient's cells. For this to be effective, the cells need to be _______cells that will not passed on to offspring, but they also need to be cells that will keep dividing for the lifetime of the patient. Currently, ______ cells, which produce all the blood and immune cell types of the body, are a preferred target.What limits the use of gene therapy...

Smoking Status Lung Cancer No Lung Cancer Total Yes &n

Smoking Status Lung Cancer No Lung Cancer Total Yes 100 300 400 No 500 500 1000 Calculate the risk of developing lung cancer among the exposed group Calculate the risk of developing lung cancer among the unexposed group Calculate the risk ratio of the exposed group when compared to the unexposed group Calculate the odds of developing lung cancer among the diseased group Calculate the odds of developing lung cancer among the non- diseased group Calculate the exposure odds ratio...

How to connect Lung cancer with the following topics. We have to somehow connect lung cancer...

How to connect Lung cancer with the following topics. We have to somehow connect lung cancer with these two expectations together and write an essay. I just need some ideas. Thanks B1. analyze the effects of various human activities on the diversity of living things; B3. demonstrate an understanding of the diversity of living organisms in terms of the principles of taxonomy and phylogeny

In a study comparing two treatment options for lung cancer, men with stage 2 lung cancer...

In a study comparing two treatment options for lung cancer, men with stage 2 lung cancer are randomized into two groups to receive either a new immunotherapy or traditional chemotherapy. These men are then followed for 1 year to determine if there are any differences in lung cancer survival rate into two groups. What kind of study is this? EPIDEMILOLOGY

nursing care plan for lung cancer

calculating allele frequencies in a gene pool

In the beetles described in the animation, there were two alleles for color, brown and green. Suppose that you discover a very small population of these beetles, consisting of the individuals shown below. How can you calculate the frequency of each allele in this population? 1) to calculate the frequency of brown allele, count the number of ___ and divide by the total number of alleles in this population. 2) In this beetle population the number of brown alleles is...

One of the genes that is commonly mutated in skin cancer is the gene that codes...

One of the genes that is commonly mutated in skin cancer is the gene that codes for the p53 protein. If both copies of the gene are mutated by UV light and the p53 protein is no longer functioning in a skin cell, the cell is not necessarily cancerous despite these mutations. However, descendants of that cell are likely to develop into cancer. Explain why having defective p53 proteins might lead to cells with many mutations present – a cancer-prone cell.

The genetic basis of cancer is complex. Choose one of these contributors and describe their effects...

The genetic basis of cancer is complex. Choose one of these contributors and describe their effects on the development of cancer. a. stem cells b. gatekeeper, driver, and passenger mutations c. oncogenes d. defective tumour-suppressor genes

QUESTION 6 The most common on all cancers is: Breast cancer Lung cancer Prostate cancer Skin...

QUESTION 6 The most common on all cancers is: Breast cancer Lung cancer Prostate cancer Skin cancer

The normal chemokine receptor 5 gene (CCR5) allele “+” and a variant allele D was found...

The normal chemokine receptor 5 gene (CCR5) allele “+” and a variant allele D was found in a population of people. The variant D has a deletion of 32 base pairs called “Delta 32”. A sample of people from this population were tested for the variation in the CCR5 gene. The researchers found 16 people were homozygous for Delta 32; 165 people were heterozygous for the Delta 32 deletion; 433 people did not have the Delta 32 deletion. Choose all...

Question