Question

Please describe at least two metabolites that can directly connect carbohydrate metabolism with nucleoside metabolism, and explain how the connection are made

Answer 1

Glucose-6-phosphate

Glyceraldehyde-3-phosphate

Fructose-6-phsophate.

These 3 are intermediates of glycolysis (carbohydrate metabolism) and pentose phosphate pathway which produces ribose-5-phsophate required for nucleotide biosynthesis (nucleoside metabolism).

Glucose-6-phosphate is converted via 3 irreversible steps into ribulose-5-phosphate which is then converted reversibly to either ribose-5-phosphate or xylulose-5-phosphate.

Ribose-5-phosphate and xylulose-5-phosphate can be converted reversibly to sedoheptulose-7-phsopahte and glyceraldehyde-3-phosphate.

Sedoheptulose-7-phsopahte and glyceraldehyde-3-phosphatecan also be converted to fructose-6-phosphate and erythrose-4-phosphate which along with xylulose-5-phosphate forms fructose-6-phsophate and glyceraldehyde-3-phosphate.