Question

In: Biology

Please describe at least two metabolites that can directly connect carbohydrate metabolism with nucleoside metabolism, and...

Please describe at least two metabolites that can directly connect carbohydrate metabolism with nucleoside metabolism, and explain how the connection are made

Solutions

Expert Solution

Glucose-6-phosphate

Glyceraldehyde-3-phosphate

Fructose-6-phsophate.

These 3 are intermediates of glycolysis (carbohydrate metabolism) and pentose phosphate pathway which produces ribose-5-phsophate required for nucleotide biosynthesis (nucleoside metabolism).

Glucose-6-phosphate is converted via 3 irreversible steps into ribulose-5-phosphate which is then converted reversibly to either ribose-5-phosphate or xylulose-5-phosphate.

Ribose-5-phosphate and xylulose-5-phosphate can be converted reversibly to sedoheptulose-7-phsopahte and glyceraldehyde-3-phosphate.

Sedoheptulose-7-phsopahte and glyceraldehyde-3-phosphatecan also be converted to fructose-6-phosphate and erythrose-4-phosphate which along with xylulose-5-phosphate forms fructose-6-phsophate and glyceraldehyde-3-phosphate.


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