Question

A patient with high levels of bilirubin and high alkaline apethase levels. what is the diagnosis?

Answer 1

Jaundice is a clinical manifestation of disorder or underlying biliribin metabolism, hepatocellular disfunction, or billary obstruction.

Clinical presentation of yellowing Eyes or skin can be somewhat no specific for the underlying etiology of diseases, stepwise approach to evaluation is necessary for diagnosis and effective treatment plan.

In this review, we discuss underline mechanism of cholestasis and jaundice as well as Laboratories and imaging modalities needed to evaluate a patient presenting with hyperbilirubimia.

Jaundice occurs in setting of cholestasis or inability to effective secret bile as well as disorder of bilirubin metabolism and hepatocellular dysfunction.

Clinical sign of Jaundice occure when the serum belurubin level exceeds .

In all cases evalution beings with lever chemistry tests which include bilirubin, alkaline phosphate, alanin aminotransfarase , is usually elevated. In this cases evalution of hepatic synthetic fuction is crucial to the formulation of a treatment paln.

When serological evalution is combined hipatobilary imaging. Underline mechanism of diseases can often be elucidated A stepwise approch to evaluation can be cost and time saving as well as a framwork to improve patient outcomes. In this review, we will outline a diagnostic approach to joundice being with pathophysiology of cholestasis followed by hyperbilirubinemia and marker of synthetic dysfunction.

Bilurubin level high - joundice

Alkaline aphetase level high - bone metastatic