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Order: Retrovir (zidovudine) 150 mg added to 150 mL of D5W to be administered by IV...

Order: Retrovir (zidovudine) 150 mg added to 150 mL of D5W to be administered by IV infusion q4h. Run over 1 hour with a 15 gtt/mL administration set.

Stock available: Retrovir 10 mg/mL IV infusion solution 20-mL single-use vial (must be diluted for administration)

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How many milliliters of Retrovir should be added to the IV fluids?

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How many mL of fluids will be infused with each dose?

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What is the drip rate for the infusion?

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How many milliliters of Retrovir will be discarded from the vial with each dose?

Expert Solution

A 20ml vial of Retrovir contains 10 mg/mL IV infusion solution

So 1ml of injection contains 10mg of the drug

1 Vial of Retrovir = 20ml solution

20ml (one vial in total) contains 20 x 10 = 200mg.

Amount of Retrovir required per dose to be administered = 150mg in 150ml of D5W

Question 1: How many milliliters of Retrovir should be added to the IV fluids?

Answer : 15ml

We need only 150 mg of drug from the 200mg (20ml) vial

Method 1: 20 ml = 200 mg

Xml = 150mg

[Applying cross multiplication]

200X = 150 x 20

200X = 3,000

So X = 3,000 / 200 = 15

So 15ml = 150mg.

[Method 2: 1 ml = 10 mg, so 15 ml gives 150mg ]

Question 2: How many mL of fluids will be infused with each dose?

Answer : 165ml.

As stated in the question 150mg Retrovir to be added to 150ml D5W over 1 hour with a 15 gtts/mL administration set.

So 150mg Retrovir = 15ml of injection

150ml D5W + 15ml of Retrovir = 165ml

So total amount of fluid = 165ml.

Question 3: What is the drip rate for the infusion?

Answer : 41 gtts/min

Order is to administer Inj. Retrovir 150 mg (15ml) added to 150 mL of D5W 4th hourly over 1 hour with a 15 gtts/mL administration set.

Drops per minute = (Total volume to be administered x Drop factor (gtts/mL) / Time in minutes

Total volume to be administered = 165ml

Drop factor (gtts/mL) = 15 drops per min

Time in minutes = 1 hour = 60minutes

Drops per minute = (165 x 15) / 60

= 41.25 which can be rounded off as 41 drops per minute.

Question 4: How many milliliters of Retrovir will be discarded from the vial with each dose?

Answer : 5ml

Each vial contains 20ml from which only 15 ml is required as per the required dose. So 5ml will be remaining after withdrawing the required amount for each dose.

Nightingale answered 2 years ago

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