The intravenous infusion of fructose into healthy volunteers leads to a two- to fivefold increase in...

The intravenous infusion of fructose into healthy volunteers leads to a two- to fivefold increase in the level of lactate in the blood, a far greater increase than that observed after the infusion of the same amount of glucose. (a) Why is glycolysis more rapid after the infusion of fructose? (b) Based on your answer to question (a), why is the use of fructose in place of glucose for intravenous feeding unwise?

Expert Solution

a) The fructose is an intermediate of glucose metabolism. Aldolase B coverts fructose-1-phosphate into glyceraldehyde and dihydroxyacetone phosphate(DHAP). Glyceraldehyde is then phosphorylated by triode kinase to glyceraldehyde-3-phosphate. Thus fructose metabolism essentially results in intermediates of glycolysis.The fructose 1-phosphate pathway forms glyceraldehyde 3-phosphate, so glycolysis more rapid after the infusion of fructose.

b) Phosphofructokinase, a key control enzyme, is bypassed. Furthermore, fructose 1-phosphate stimulates pyruvate kinase, so the use of fructose in place of glucose for intravenous feeding unwise.

gladiator answered 2 years ago

An intravenous infusion contains 25,000 units of heparin in 250mL D5W. The rate of infusion was...

An intravenous infusion contains 25,000 units of heparin in 250mL D5W. The rate of infusion was set at 15 units / kg /hr. The patient weighs 160 pounds. Calculate the a) Concentration of heparin, b) the length of time of infusion, c) the dose of heparin administered to the patient on a unit/ min basis.

A physician prescribes an intravenous infusion of Drug X for a patient. The drug is to...

A physician prescribes an intravenous infusion of Drug X for a patient. The drug is to be administered at a rate of 2.5 mg/min for 4 hours. The total volume of the IV solution is 250ml. Calculate the drip rate in drops per minute if the dropper set delivers 20 drops per milliliter. The rate of the infusion= ______ drops/minute

Recognize the terms: biologic therapy and moderate sedation/analgesia using intravenous infusion, Select one of the two...

Recognize the terms: biologic therapy and moderate sedation/analgesia using intravenous infusion, Select one of the two therapies listed in the objective above, and discuss an important aspect for nursing consideration, related to the therapy. Utilize the Infusion Nursing Standards of Practice as your reference.

For children, heparin sodium is administered by intermittent intravenous infusion in a range of 50 to...

For children, heparin sodium is administered by intermittent intravenous infusion in a range of 50 to 100 units/kg body weight every 4 hours. For a 50-lb. child, calculate the range, inmilliliters, of a heparin sodium injection containing 5000 units/mL to be administered daily. NOTE: The answer should be 1.36 to 2.73mL heparin sodium injection

You have been assigned to care for a patient who is to receive an intravenous infusion...

You have been assigned to care for a patient who is to receive an intravenous infusion of oxytocin to induce labor. The patient was admitted to the hospital 2 days ago for dehydration related to the flu. What information should you obtain before starting the drug therapy? Is the patient’s recent dehydration a consideration? If so, in what way? Is any special equipment needed to administer oxytocin? What monitoring should be done during oxytocin infusion? For what complications that may...

A patient is receiving an intravenous infusion containing 35 mEq KCL and there is 150 mL...

A patient is receiving an intravenous infusion containing 35 mEq KCL and there is 150 mL remaining in the IV bag. What's the amount of fluid infused?

A patient is ordered to receive sodium supplementation by intravenous infusion of a sodium phosphate dibasic...

A patient is ordered to receive sodium supplementation by intravenous infusion of a sodium phosphate dibasic solution [Na2H PO4 , MW=141.96 g/mol]. The patient is ordered to receive 0.5 mEq of Na + ions per hour. A 500 mL intravenous bag is prepared that contains 47 mL of a 1% solution of sodium phosphate dibasic. What should be the infusion rate (in units of mL/min) necessary to produce the ordered dose of 0.5 mEq/hr of sodium? (Note: Consider the total...

1. A physician orders 2000 units of heparin to be administered by intravenous infusion per hour. The...

1. A physician orders 2000 units of heparin to be administered by intravenous infusion per hour. The pharmacy provides a heparin IV bag containing 25,000 units of heparin in 250 ml of D5W. How many ml should be administered per minutes? 2.A male patient weighing 85 kg is placed on heparin therapy for the prevention of deep vein thrombosis after surgery. How many ml of a heparin injection containing 5000 units/ml should be administered for a loading dose of 75 units/kg? 3. Following...

An intravenous infusion for a patient weighing 132 lb calls for7.5 mg of amikacin sulfate...

An intravenous infusion for a patient weighing 132 lb calls for 7.5 mg of amikacin sulfate per kilogram of body weight to be added to 250 mL of 5% dextrose injection. How many milliliters of an amikacin sulfate injection containing 500 mg/2 mL should be used in preparing the infusion?

Infusion of ______________ intravenous solutions promotes movement of water into cells, thus making the cells swell....

Infusion of ______________ intravenous solutions promotes movement of water into cells, thus making the cells swell. A.Isotonic B.Hypertonic C. Hypotonic

Question