Why is binding of hFGF-1 to heparin important

Expert Solution

Ans. heparin/heparan sulfate are believed to be required for binding
of FGF-1 to their high affinity receptor. The FGFs bind to heparin and to the glycosaminoglycan chain of heparan sulfate which enhance mitogenic activity of them, particularly FGF-1. A recent model of Pantoliano et al, complex FGF- 2/heparin/FGF.R1 (1:1:2) where receptor dimerization would be responsible for cross phosphorylation and signal transduction.

gladiator answered 2 years ago

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