Question

A hybrid protein resulting from the fusion of two chromosomes (chromosome 22 and chromosome 9) following a translocation can result in this type of cancer

Question 30

	1) Chronic Myeloid Leukemia
	2) Lung Cancer
	3) Breast Cancer
	4) Familial adenomatous polyposis (FAP)
	5) Hereditary nonpolyposis colon cancer (HNPCC)

The ability of cancer cells to move to different tissues is known as

Question 33

	1) Dysplasia
	2) Angiogenesis
	3) malignancy
	4) Metaplasia
	5) Metastasis

Answer 1

Question 30
A hybrid protein resulting from the fusion of two chromosomes (chromosome 22 and chromosome 9) following a translocation can result in this type of cancer
Answer: 1. Chronic Myeloid Leukemia

Explanation :
A hybrid protein resulting from the fusion of chromosome 22 and chromosome 9 following a translocation can result in Chronic Myeloid Leukemia.
CML is usually resulted from a specific chromosomal abnormality called the Philadelphia (Ph) chromosome, named after the city where it was first recorded. The Ph chromosome is the result of a translocation—or exchange of genetic material—between the long arms of chromosomes 9 and 22 . This exchange brings together two genes: the BCR (breakpoint cluster region) gene on chromosome 22 and the proto-oncogene ABL (Ableson leukemia virus) on chromosome 9. The resulting hybrid gene BCR-ABL codes for a fusion protein with tyrosine kinase activity, which activates signal transduction pathways, leading to uncontrolled cell growth.

Question 33
The ability of cancer cells to move to different tissues is known as
Answer: 5. Metastasis

Explanation :
Cancer cells have the ability to move to different tissues of the body and invade them, this property of the cancer cells is known as Metastasis.
Metastasis, from the Greek methistanai, meaning to move to another place, describes the ability of cancer cells to penetrate into lymphatic and blood vessels, circulate through these systems and invade normal tissues elsewhere in the body.