Question

How are the subsets of the Classical macrophage activation and the Alternate macrophage activation regulated?

Answer 1

• The term macrophage activation was introduced by Mackanew in 1960 ' s .      macrophages are endowed with avariety of receptors for lineage determining growth   factors , T helper cell cytokinesis ,   and B cell ,host , and microbial products . in tissyes ,   macrophages mature and are activated in a dynamic response to combinations of there stimuli to acqurie specalised functional phenotypes ,   the concept of classic and alternative activation , also termed M1 and M2 to mimic . macrophage evolved in simple multicellar organims to performphagocytic clearence of dying cells in development and adult life , and to protect the host through innate immunity. macrophages are key modulators and effector cells in the immune response , their activation influences and responds to other arms ofthe immune system . genetic functional signature acquried   during   maturation and activation   and considerd    M1M2   in model of macrophage polarisation , in vitro studies , macrophage activation   and as disscussed ,ko animals for key cytokinesis and receptors have established a role for   some of these in the development and maturation of macrophages. M1 and M2 activation display   differences but also   overlapping   effects that need clrification   and a more   dynamic appreciation   of the activation process.