Question

In: Chemistry

1. Glycogen: a.)  Is mainly broken down to glucose-1-P by glycogen synthase b.)  Has branch chains that...

1. Glycogen:

a.)  Is mainly broken down to glucose-1-P by glycogen synthase

b.)  Has branch chains that are attached at the branch points by alpha 1,4

glycosidic linkages

c.)  Built by glycogen phosphorylase when there is high ATP and high glucose-6-

P

d.)  Is an important storage form of glucose in our livers

e.)  Both a and c 

2. What effect will high fructose-2,6-bisphosphate and low ATP have on gluconeogenesis?

a.)  It will shut gluconeogenesis down at the step of triose phosphate isomerase

b.)  It will speed gluconeogenesis up at fructose-1,6-bisphosphate phosphatase

c.)  It will speed up gluconeogenesis by hyperactivating triose phosphate

isomerase

d.)  It will speed up gluconeogenesis by hyperactivating phosphofructokinase

e.)  Both b and d

Solutions

Expert Solution

1-Option d is correct

Glycogen is an important storage form of glucose in our livers (Insulin acts on the hepatocytes to stimulate the action of several enzymes, including glycogen synthase. Glucose molecules are added to the chains of glycogen as long as both insulin and glucose remain plentiful.)

2.)

d) Is correct option.( high fructose-2,6-bisphosphate and low ATP will speed up gluconeogenesis by hyper activating phosphofructokinase. Phosphofructokinase, which catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6- bisphosphate, a key regulatory step in the glycolytic pathway. Fructose bisphosphatase is an enzyme that converts fructose-1, 6-bisphosphate to fructose 6-phosphate in gluconeogenesis and the Calvin cycle which are both anabolic pathways.. More specifically, fructose 2,6-bisphosphate inhibits fructose 1,6-bisphosphatase, but activates phosphofructokinase. The rate of gluconeogenesis is ultimately controlled by the action of a key enzyme, fructose-1,6-bisphosphatase.)


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