100.In brain tissue, glucose-6-P is not converted into glucose.True/False? 99.Pyruvate, glycogen and glutamate are the major...

100.In brain tissue, glucose-6-P is not converted into glucose.True/False?

99.Pyruvate, glycogen and glutamate are the major products of glucose-6-P which is one of the three key metabolic intermediates.True/False?

98.Metabolic specialization of organs is exemplified by the presence of glucose-6-phosphatase in the liver and kidneys but not in muscle.True/False?

97.The inhibition of xanthine oxidase activity by allopurinol will result in the accumulation of hypoxanthine and xanthine.True/False?

96.Patients with gout have elevated levels of serum uric acid.True/False?

95.Nucleoside monophosphate kinase and nucleoside diphosphate kinases are involved in converting the nucleoside-5'-monophosphate (NMP) products of the purine or pyrimidine biosynthesis pathways into their 5'-triphosphate (NTP) derivatives.True/False?

94.The conversion of IMP to AMP is involved in the salvage reactions of purine synthesis. True/False?

Solutions

Expert Solution

100. True. In brain tissue glucose-6-p is not converted into glucose; the process is called as gluconeogenesis which is normally present in liver,kidney, intestine and muscle.

99. True. Pyruvate, glycogen and glutamate are the major products of glucose-6-P which is one of the three key metabolic intermediates.

v98. True.The presence of glucose-6-phosphatase in the liver and kidneys but not in muscle.glucose 6-phosphate generated from glycogenolysis and glucogenesis is released from the liver into the circulation for peripheral use. There does not appear to be glucose 6-phosphatase in skeletal muscle; hence, muscle glycogen is not a source of circulating glucose.

97, False. Inhibition of xanthine oxidase by allopurinol prevents the metabolism of hypoxanthine and xanthine to uric acid, which should result in elevated levels of hypoxanthine and decreased production of xanthine and uric acid.

96. False. Measurement of serum uric acid is the most misused test in the diagnosis of gout. The presence of hyperuricemia in the absence of symptoms is not diagnostic of gout. In addition, as many as 15% of patients with symptoms from gout may have normal serum uric acid levels at the time of their attack.

gladiator answered 1 year ago

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