Question

A vaccine company working on an inhaled COVID19 vaccine wants to assure that B cells and T cells form cognate pairs so that a germinal center will ultimately be formed.
A. What signals will the SARSCoV2-reactive TFH and B cell need to form a cognate pair?
B. In a research animal, where would you find this cognate pair together (specific anatomical location)?

Answer 1

A) Follicular helper T (Tfh) cells are specialized providers of T cell help to B cells, and are essential for germinal center formation, affinity maturation, and the development of most high affinity antibodies and memory B cells. which can provide protection against reinfection.

The severe acute respiratory syndrome coronavirus 2(SARS_CoV_2)is the causative agent of current coronavirus disease and pandemic completely widespread all over the world. Also made many significant changes in the earth .

The type of comparison is essential to understanding the contribution of T and B cell responses to viral clearance and the mechanisms behind immunopathology. The research of germal center can be pathogenic hotspot for the production of antibodies in autoimmune diseases.

High affinity B cells and follicular helper T(TFH) cells shows their locations in GCs and thus GC formation.T cell activation and lymphopenia are associated with disease severity in COVID-19.

The S- specific antibodies shows B cells and (TFH) are consistently generate after SARS-COV-2 infection. Which robust humoral immunity and positively associated which plasma neutralising activity.

B) Lymph nodes where, the cognate pairing of B cells and follicular helper T cells happening.

B cell receptor–initiated signals in mature lymphocytes are vital for Ag-activated B cell proliferation and clonal expansion .