explai the different types of mutations and how tgey occur

Solutions

Expert Solution

Missense mutation, which results in a protein in which one amino acid is substituted for another. It is due to point mutation. Example sickle cell anemia

Nonsense mutation, in which a stop codon replaces an amino acid codon, leading to premature termination of translation. It is due to point mutation.

Frameshift mutation, which causes a change in the reading frame, leading to introduction of unrelated amino acids into the protein, generally followed by a stop codon.
It is due to insertion or deletion of DNA sequence. One form of beta-thalassemia.

Point mutation is due to ethylmethane sulfonate (EMS).

Chromosomal mutation
Inversion - One region of a chromosome is flipped and reinserted.
Duplication - A region of a chromosome is repeated.
Translocation - A region from one chromosome is aberrantly attached to another chromosome. Burkitt lymphoma.

gladiator answered 1 year ago

Next > < Previous

Related Solutions

Explain the different types of mutations that can occur in DNA and their potential severity in...

Explain the different types of mutations that can occur in DNA and their potential severity in a protein product.

Describe how spontaneous point mutations occur in bacteria. How may these types of mutation affect protein...

Describe how spontaneous point mutations occur in bacteria. How may these types of mutation affect protein function?  Explain the function and importance of genetic variation in bacteria. Include in your answer descriptions of two examples where genetic variation has resulted in differences in the behaviour of different bacterial strains of the same species.

Give an example of 5 different types of Gene mutations

How do mutations occur and how can environmental factors increase mutation rates? How do mutations affect...

How do mutations occur and how can environmental factors increase mutation rates? How do mutations affect proteins and their expression? Does the location of the mutation within a gene matter to phenotype expresion, if so, how? How do mutations affect phenotypes? Can we predict the impact of a mutation on protein activity? What are loss-of-function and gain-of-function mutations?

Germline mutations occur in sperm or egg and are heritable, whereas somatic mutations occur in non-germ...

Germline mutations occur in sperm or egg and are heritable, whereas somatic mutations occur in non-germ cells and are not heritable. Imagine that you are working in a laboratory which is studying on tissue/cell specific mutation pattern. You have all the tools (such as cell culture, imaging, sequencing etc.) and materials (such as genomic DNA, tissue and primary fibroblast cells from a human individuals). By using a NGS analysis please set up experiments/pipeline, including which method/algorithm would you use to...

What effect on phenotype will occur on the following types of mutations: 1. Base Substitution 2....

What effect on phenotype will occur on the following types of mutations: 1. Base Substitution 2. Thymine Dimers 3. Indels 4. Nucleotide Expansion 5. Larger lesions (duplication, deletions, inversion, translocation)

how do different types of stroke events occur and how TPA is used to treat this...

how do different types of stroke events occur and how TPA is used to treat this on both a cellular and molecular level. focus on structure function and relationship between TPA and clots- discuss mechanism by which this works

Describe how protein/DNA interactions occur. How does a protein bind to DNA? Are there different types...

Describe how protein/DNA interactions occur. How does a protein bind to DNA? Are there different types of DNA binding proteins? Can they be specific to a sequence in the DNA?

The different types of cells are not randomly distributed throughout the body; rather they occur in...

The different types of cells are not randomly distributed throughout the body; rather they occur in organized layers, a level of organization referred to as

mutaions types: “synonymous” “nonsynonymous” mutations. “silent” “noisy”. “missense”, “nonsense”, and “sense” mutations. if mutations (and evolutionary...

mutaions types: “synonymous” “nonsynonymous” mutations. “silent” “noisy”. “missense”, “nonsense”, and “sense” mutations. if mutations (and evolutionary base substitutions) were truly random, then which of these categories of mutations would you expect to occur most often in protein coding sequences? Second most often?If you restricted your attention to the third codon position, then which category of mutation would you expect to occur most often? and why ?

Subjects