In: Nursing
You are
. . . a physician’s assistant (PA) in the Genetic Counseling Clinic at Fulwood Medical Center.
Your patient is
. . . Mrs. Patricia Bennet, a 52-year-old office manager with two daughters, aged 30 and 25. Mrs. Bennett’s sister, aged 55, recently had a mastectomy for breast cancer and is now receiving chemotherapy. Their mother died of ovarian cancer in her late fifties.
Since the patient has hereditary connection of mother died with
ovarian cancer this may be viewed in terms of Hereditary breast and
ovarian cancer syndrome (HBOC).
This syndrome is caused by inherited mutations in the genes BRCA1
and BRCA2, as well as possibly some other genes that have not yet
been found. This syndrome is linked to a high risk of breast cancer
as well as ovarian, fallopian tube, and primary peritoneal
cancers.
Mutations in BRCA1 and BRCA2 are also responsible for most
inherited ovarian cancers. Mutations in BRCA1 and BRCA2 are about
10 times more common in those who are Ashkenazi Jewish than those
in the general U.S. population.
The lifetime ovarian cancer risk for women with a BRCA1 mutation is
estimated to be between 35% and 70%. This means that if 100 women
had a BRCA1 mutation, between 35 and 70 of them would get ovarian
cancer. For women with BRCA2 mutations the risk has been estimated
to be between 10% and 30% by age 70. These mutations also increase
the risks for primary peritoneal carcinoma and fallopian tube
carcinoma.
In comparison, the ovarian cancer lifetime risk for the women in
the general population is less than 2%.