Question

1. Late detection of tumours has 3 significant consequences. Which of the following is NOT one of them?
a) Risk of metastases is highest
b) Larger tumours are less responsive to drug therapy
c) Patients tolerability to treatment is reduced
d) Complete surgical removal is impossible

2. Which of the following does not explain why the immune system contributes little to killing cancer cells?
a) Certain cancers compromise the immune system directly
b) Difficult recognition of cancer cells by immune cells
c) Immunosuppression is a common adverse effect of chemotherapy
d) Cancer cells divide faster than the immune cells can kill them

3. You are a young scientist in a hospital cancer lab. You are analyzing the behavior of a tumor biopsy sample from a hospital patient. The physician needs your test results for the appropriate chemotherapy selection. You find out that the tumour is synthesizing abnormally high amounts of adenine & guanine. Which of the following drugs should be avoided because most likely it will be ineffective?
a) Cytarabine
b) Methotrexate
c) Fluorouracil
d) Mercaptopurine

4. Which drug has been used to try to reverse tumour multiple drug resistance acquisition?
a) Methotrexate
b) Aspirin
c) Valproate
d) Cyclosporine

5. Dexrazoxane is only indicated in patients receiving doxorubicin for breast cancer therapy. Why is that?
a) Breast cancer patients have higher risk of doxorubicin cardiotoxicity
b) Dexrazoxane is primarily distributed inside fatty tissues of the breast
c) Myelosuppression is too important with other cancers
d) It has only been studied in breast cancer patients so far

Answer 1

1. Option D is the correct option as all rest are observed in these patients

2. Option B is correct as due to difficult recognition of cancer cell and normal cell this problem arises

3. Option D is correct as 6-mercapto purine should be avoided

4. Option C is correct as valproic acid is used for this purpose in case of certain tumors

5. Option C is correct it’s due to severity of Myelosuppression