Johnny Tisoy, an elderly man living in a Nursing Home, has a diagnosis of schizophrenia. He...

Johnny Tisoy, an elderly man living in a Nursing Home, has a diagnosis of schizophrenia. He is delusional and hallucinatory at times. Patient Tisoy was on oral chlorpromazine hydrochloride (Thorazine) 50 mg three times daily (TID) for over a year. Then, the physician changed his medication to oral haloperidol (Haldol) 5 mg TID. He has been taking haloperidol for the past 3 weeks.

How will a nurse determine which of the two drugs (chlorpromazine and haloperidol) is more potent than the other?
Why is efficacy more important than potency? Which drug is more efficacious?

Describe the graded-dose response, and discuss how it is relevant to nursing practice.

Solutions

Expert Solution

Schizpphrenia is a disorder that affects a persons aility to think feel and behave clearly, the nurse can identify the effectiveness of the two medications by assessing the seviority of the symptoms of the patient by giving the doses, and close examine the patient both events.Potency is an expression of the activity of a drug in terms of the concentration or amount of the drug required to produce a defined effect whereas clinical efficacy judges the therapeutic efffectiveness of the drug in humans, so by accessing the symptoms of the Johny Tisoy we can identify the more efficacious drug,

Currently available data shows that haloperidol and chlorpromazine are similarly effective for treatment of schizophrenia. But at least at higher doses haloperidol seems to be associated with more extrapyramidal side effects while hypotention appears to occur more frequently when chlorpromazine is used.

Adjust dosage to individual and the severity of hos condition recognizing that the milligram for milligram potency relationship among all dosage forms has not beenn precisely estalished clinically.The 100 mg and 200 mg tablets are for use in severe neuropsychiatric conditions.

Nightingale answered 1 year ago

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