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QUESTION 30 The normal activity of the retinoblastoma (Rb) protein in the cell is to: A....

QUESTION 30

The normal activity of the retinoblastoma (Rb) protein in the cell is to:

A. block the initiation of anaphase during the cell cycle.

B. inhibit p53 activity.

C. induce cyclin–CDK complex formation.

D. regulate the progression of from G1 to S in the cell cycle.

E. suppress transcription of tumor-suppressor genes.

QUESTION 32

  1. Which of the following is the major event associated with the retinoblastoma cancer?

    A.

    a translocation resulting in the enhanced expression of an oncogene

    B.

    inactivation of a major DNA repair system

    C.

    a translocation involving chromosomes 9 and 22

    D.

    a mutation resulting in an activated RAS oncogene

    E.

    both copies of a tumor-suppressor gene being inactivated

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