Question

discribe the function of a specific intron within the gene-codeing region for the protien keratin

Answer 1

function of specific Intron within gene codeing region of protein keratin32

intron is segment of a DNA or RNA molecule which does not code for proteins and interrupts the sequence of genes I t is a polynucleotide sequence in a nucleic acid that does not code information for protein synthesis and is removed before translation of messenger RNA -compare exon.

while Introns donot encode protein products , they are integral togene expression regulation. some introns themselves encodefunctionalRNAS through futher processing after splicing to generate noncoding RNA molecules. Alternative splicing is widely used to generate multiple proteins froma single gene.

Keratin synthesis is regulated in at the level of transcription. each keratin genes appears to be regulated by a characteristic constellation of transcription factors and DNA binding sites,. Often these occur in clusters and complexes ,providing a mechanism for fine tuning the expressionlevels . Most commonly the important regulatory sites are found in the promoter regions ,infrequently coding and downstreamsequences also play a role

transcription factors sp1,AP1 and AP2 are important components in regulation of many keratin genes,and the nuclear receptors for retinoic acidand thyroid hormone also regulate majority of keratins .in addition,the expression of most keratin genes can be modulated by extracellular signals , such as growth factors.

Universal o r general regulators for all keratin genes have not been found , apparently each keratin protein has its own , characteristic circuits and machinery for regulation of expression