Question

True or False

1.Rise in ketone bodies in blood parallels an increase in blood glucose concentration.

2.Glutamate dehydrogenase catalyzes a metabolically irreversible and redox-active reaction.

Answer 1

1. An increase in blood glucose level indicates that glucose is not being absorbed by the cells. Under these circumstances when the glucose is not absorbed and thus there is no energy obtained by breaking of glucose molecules, as a bypass pathway ketone bodies are produced in the liver by the oxidation of fatty acids so that energy is obtained via that pathway and compensated for glucose that cannot be utilized.

More the amount of blood glucose level, less is the amount of energy produced by glucose metabolism and more is the utilization of the fatty acids to form ketone bodies and provide energy to the cell.

So more blood glucose means rise in ketone bodies in the blood- the statement is TRUE.

2. Glutamate dehydrogenase converts glutamate to α-ketoglutarate and ammonia in a reversible reaction. This reaction also reduces NAD(P)+ to NAD(P)H along with the formation of α-ketoglutarate and ammonia.

Thus statement 2 which states that Glutamate dehydrogenase catalyzes a metabolically irreversible and redox-active reaction is FALSE.