Question

An example of a non-biologic Disease Modifying Anti-rheumatic Drug (DMARD) is _________ and will cause __________.

Select one:

A. Celecoxib; reduces prostaglandins from the COX-2 pathway and general inflammatory cytokines.

B. Corticosteroids; reduced pro-inflammatory cytokines and chemical mediators of inflammation

C. Rituximab; reduced B lymphocyte functions

D. Methotrexate; reduced pro-inflammatory cytokine release and phagocytic cell chemotaxis

Answer 1

ANSWER :

Option D : Methotrexate ; reduced proinflammatory cytokine release and phagocytic cell chemotaxis.

An example of a non biologic Disease Modifying Anti rheumatic drug(DMARD) is Methotrexate and will cause reduced proinflammatory cytokine release and phagocytic cell chemotaxis.

Reason :

Celecoxib :

• It is a COX -2 selective NSAID (Non steroidal anti inflammatory drug).
• It is a COX -2 inhibitor which prevents synthesis of prostaglandins(mediators of pain and inflammation).
• NSAID'S are first line drugs and afford symptomatic relief in pain ,swelling , morning stiffness ,immobility ,but do not rest the disease process.

Corticosteroids:

• They are adjuvant drugs which are used along with DMARDS.They have potent immunosuppressant and antiinflammatory activity.

Rituximab :

• It is a biologic DMARD which is used in refractory rheumatoid arthritis by selectively reducing B - lymphocyte functions.

Methotrexate:

• It is a non-biologic DMARD which has prominent immunosuppressant and antiinflammatory property.
• It is dihydrofolate reductase inhibitor.
• It inhibits chemotaxis,cytokine production and cell mediated immune reaction.