Question

UAA codons are the most common termination signal used at the end of genes in E. coli. All known UAA suppressors are inefficient. At the same time, cells containing UAA suppressors are quite sick—in a global sense, the bacterial cells do not function well. Propose an explanation for the relative inefficiency and toxicity of UAA suppressors (compared to UAG or UGA suppressors).

Answer 1

UAA(Uracil, Adenine, Adenine is a wrong coding that spreads infection through the parasite E.Coli. These genes are normally present at the tail end of the above parasite in the gut of human being that is the cause of infection. This codon can be rectified by some suppressor which has to have such coding that would do away with the infection and kill the bacterial cells.

The suppressors have to be created and its medicines manufactured in such a way that the folds in the mRNA would go through a process of translation and increase in order to put an end to the infection and multiplication of E.Coli. The multiplication of the mRNA in the human genes would reduce the toxicity of UAA.

The process of mutation in the genes of human beings may not be always bad but at times according to the constitution of the body these mutations can prove to be, stop codons like UAG or UGA. Its here where translation is needed and the role of tRNA comes into play. The tyrosine in the tRNA has to be strong enough not to decode to mRNA and allow the stop codons to multiply. Therefore in UAA suppressor mRNA has to play an important role as compared to tRNA in UAG or UGA..

UAA suppressors

Change of mRNA to tRNA