Question

AlgU is a σ factor that controls extreme stress responses in P. aeruginosa, not the protein encoded by mucC. Several other muc genes function as inhibitors of AlgU. Inhibiting the conversion to a mucoid phenotype mucC however, does not play a direct role in the inhibition of mucoidy conversion. What might be the mucC role in AlgU’s response under extreme stressed conditions?

Answer 1

In the latest study the role of mucC in P. aeruginosa is in physiology and production alginate has been addressed. Inactivation of Insertional mucC in the type-wild P. aeruginosa PAO1 - strain cause did not any overt effects on synthesis alginate . It affected However on growth of P. aeruginosa under combined elevated conditions of temperature and increased osmolarity or ionic strength. mucC of Inactivation mucB or mucA mutant backgrounds resulted in a phenotype mucoid when the cells are in were under grown in combined conditions stress of elevated osmolarity and temperature. Each factors tested of the stress separately did not cause comparable effects. The stress combined factors were not sufficient phenotypically to cause appreciable enhancement of production alginate in mucB or mucA. Unless Mutants were mucC was also inactivated.