rovide the mechanisn of action by which the following medications causes Hyponatremia (low sodium): 1) Trazodone...

rovide the mechanisn of action by which the following medications causes Hyponatremia (low sodium):

1) Trazodone

2) omeprazole

3) Aripripazole

4) Keppra.

Please attached references

Expert Solution

1. Trqzodone is an antidepressant medication. It works by inhibiting both serotonin transporter and serotonin receptor by inhibiting serotonin reuptake. It also blocks the histamine and alpha-1 adrenergic receptors. The occurrence of hyponatremia is very rare in case of Trazidone. This Serotonin receptor inhibitors causes syndrome of inappropriate ADH section. This can cause excess urine output. It can also causes side effects like diarrhoea and vomiting, this can cause loss of electrolytes. So, Trazidone can cause hyponatremia.

2. Omeprazole is a proton pump inhibitor ( PPI). This medicine causes excess urine output and this causes increased sodium output. So, Omeprazole can cause hyponatremia.

3. Aripripazole is an antipsychotic medicine. It has Serotonin mediated effects like as 5-HT2 and 5-HT1c receptor effects. This causes syndrome of inappropriate ADH section and causes excess urine output and high urine sodium concentration. By this way Aripripazole causes hyponatremia.

4. Keppra or Levetiracitum is an antiepileptic drug. The drug bindas with a synaptic vesicle glycoprotein called as SV2A and inhibits pre synaptic calcium channel and reduce nurotransmitter release. It acts as a neuromodularor. D

to repeated use of keppra it can cause SIADH ans this causes hyponatremia and increased urine sodium concentration.

Nightingale answered 2 years ago

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