Question

Questions about Cellular Neurobiology

8. Why might one observe differences in the results of in vitro vs. in vivo experiments?

Answer 1

IN vitro study:

1)"within the Glass" In this study the professional take part of a living things(cell or tissue).

2)In this the artificial environment maintain to conduct studies.

3)relatively less challenging than vivo.

4)may also called as preclinical studies.

5)this is less precise than in vivo studies.

6)this help to study of pharmacokinetic properties of drug( dissolution study)

7)less expensive.

8)less time consuming.

9)no harm to whole organism.

10)Zone inhibition study for antibiotics

In vivo study:

1)"within the living thing"In this the professional conduct the study in whole living system( human body)

2)There is no artificial control on environment. living system shows direct effect.

3)relatively more challenging than vitro.

4)may also called as clinical trials(exception, some times it done in animal and plant so this study may consider as preclinical studies).

5)this is more precise than in vitro experiment.

6)It help to study pharmacodynamic properties of drug.(Cmax , Cp)

7)more expewnsive.

8)time consuming

9)if the drug have more side effect and adverse effect than may cause harm to living system.

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