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Topic is Hodgkin's Lymphoma Definition/description of your topic (~2-3 paragraphs): An overview of key elements related...

Topic is Hodgkin's Lymphoma

Definition/description of your topic (~2-3 paragraphs): An overview of key elements related to the condition you have researched, such as history, epidemiology, populations/ages affected, transmission, and genetics, as applicable.

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Expert Solution

Hodgkin's disease

Definition

A cancer that develops in lymph system ( lymphoma), in which cancer originates from a specific type of white blood cells called lymphocytes.

History

  • First described in 1832 by Thomas Hodgkin
  • He studied in 7 patients with painless lymph node enlargement
  • Theodore langhands and WS Greenfield first described the microscopic characteristics of Hodgkin's lymphoma on 1872 and 1878 respectively

Epidemiology

  • Incidence increases with age between 15-30 and above 55
  • Increases in males than females
  • Family history of disease increase incidence

Transmission

  • Spreads through lymph vessels from lymph node to lymph nodes
  • In late cases it invade blood stream and spreads to other parts of body

Genetics

  • Genetic instability in malignant Hodgkin
  • Reed Sternberg cells in classical Hodgkin's lymphoma
  • Lymphocytic & histiocytic (L&H) cellsin lymphocyte predominant Hodgkin's lymphoma
  • DNA mutations can cause this

Signs and symptoms

  • Lymphadenopathy
  • Itchy skin
  • Night sweats
  • Weight loss
  • Pain following alcohol consumption
  • Petechiae
  • Fatigue
  • Spleenomegaly
  • Hepatomegaly
  • Back pain

Diagnosis

  • Lymph node biopsy
  • Blood test
  • PET ( positron emission tomography)

Nightingale answered 2 years ago
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