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describe the mechanism of action and adverse effects of each drug selected. (1)   Isosorbide dinitrate plus...

describe the mechanism of action and adverse effects of each drug selected.

(1)   Isosorbide dinitrate plus hydralazine

Solutions

Expert Solution

Isosorbide dinitrate

mechanism of action

  • belongs to nitrate group, moderate to long acting
  • It is a peripheral vasodialtor, it relaxes blood vessels and increases blood flow to the heart, thereby reducing the workload.Venous dilation enables pooling of blood and decreases return to the heart, decreases preload. Arterial vasodilation reduces systemic vascular resisistance and mean arterial pressure

Ref: https://www.drugbank.ca

adverse effects

  • Nausea
  • head ache
  • dizziness
  • weakness
  • syncope- occasional
  • palpiattion
  • tachyarrhythmia   

ref: https://reference.medscape.com/drug/dilatrate-sr-isordil-isosorbide-dinitrate-342276

hydralazine

mechanism of action :

Antihypertensive: direct acting antihypertensive agent. causes peripheral vasodilation by relaxing cardiac smooth muscle. Cellular calcium metabolism is altered and affects contactility. It decreases blood pressure , increases HR, CO and SV

Ref: https://www.drugbank.ca

adverse effects

  • anorexia
  • headache
  • nausea
  • vomiting
  • diarrhea
  • constipation
  • tachycardia
  • anxiety
  • stuffy nose
  • joint pains
  • skin rashes

ref: https://www.rxlist.com/apresoline-side-effects-drug-center.htm

Nightingale answered 2 years ago
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