Role of CA 15-3 in the diagnosis and monitoring of breast cancer

Solutions

Expert Solution

Before giving your answer I would like to brief you on Breast cancer.

Breast cancer is most common cancer in female in the world.

Diagnosis is made by using TRIPLE ASSESSMENT which includes - a) Clinical examination, b) Mammogram and c) Tissue diagnosis by True cut biopsy/core needle biopsy.

Now coming to CA 15-3,

What is CA 15-3? CA stands for Carcinoma Antigen and its a TUMOR MARKER which gets raised in blood in patient suffering from breast cancer. Normal level is less then 30 U/L.

Its ROLE in not for primary diagnosis of breast cancer but is MORE RELATED TO METASTATIC BREAST CANCER rather than in initial stage of breast cancer.

Now, coming to your answer -

MAIN PURPOSE Is to

1) DETECT TREATMENT RESPONSE IN METASTATIC BREAST CANCER after treatment initiation. Level of CA 15-3 should decrese with treatment.

2) SURVEY FOR RECURRENCE after completion of treatment of metastatic breast cancer i.e.after normal level achieved after completion of treatment if there is rise in CA 15-3 then it is suggestive of disease recurrence

Other than this two things there are also certain other things tobe kept in mind like

a) Higher CA 15-3 level higher is Tumor size or Advance is the disease stage

b) Metastasis of Liver and Bone is the main reason for production of CA 15-3

c) Elevation of CA 15-3 level can also be seen in other malignancy(Lung cancer, Liver cancer etc), benign disease(liver cirrhosis, sarcoidosis) or even healthy individual.

Nightingale answered 1 year ago

Next > < Previous

Related Solutions

Breast cancer

Exercise 1: Thirty nine women with a diagnosis of inoperable or metastatic breast cancer have been...

Exercise 1: Thirty nine women with a diagnosis of inoperable or metastatic breast cancer have been followed-up for a number of years, while under continuous treatment with a medication called trastzuzumab. The time (in months) each patient remained in remission was recorded. Remission is is a decrease or disappearance of signs and symptoms of cancer. Below is the data. 50 74 35 39 21 37 27 35 30 35 26 38 34 34 26 41 61 33 33 26 25...

thirty-nine women with a diagnosis of inoperable or metastatic breast cancer have been followed-up for a...

thirty-nine women with a diagnosis of inoperable or metastatic breast cancer have been followed-up for a number of years, while under continuous treatment with a medication called trastuzumab. the time (in months) each patient remained in remission was recorded. Remission is a decrease or disappearance of signs and symptoms of cancer. Below is the data. 50 74 35 39 21 37 27 35 30 35 26 38 34 34 26 41 61 33 33 26 25 41 35 34 44...

A mammogram was used to screen for breast cancer in 200 women with breast cancer diagnosed...

A mammogram was used to screen for breast cancer in 200 women with breast cancer diagnosed by a biopsy and in 500 age- and race-matched women without breast cancer. The results of the mammogram were positive in 150 of the women with breast cancer and in 100 of the women without breast cancer. b. Compute the i) sensitivity, ii) specificity, iii) positive predictive value, and iv) negative predictive value. c. Make a statement about each of the computations d. If...

14. If cancer cells from breast cancer enter the lymphatics of the breast, where are they...

14. If cancer cells from breast cancer enter the lymphatics of the breast, where are they likely to lodge and start new growths? Explain why, using your knowledge of the anatomy of the lymphatic and circulatory systems. 19. Explain why lymphedema may occur after breast surgery. 5. What is the function of interferon? 14. What are cytokines? Lymphotoxins? 10. Briefly, what role, if any, does each of the following hormones play when the body id subjected to stress: ACTH, ADH,...

40years old Amish female diagnosis with breast cancer list the nursing consideration and teaching need consider...

40years old Amish female diagnosis with breast cancer list the nursing consideration and teaching need consider the culture

Please explain how apoptosis affect and form breast cancer, what factors are contributed to breast cancer...

Please explain how apoptosis affect and form breast cancer, what factors are contributed to breast cancer formation?

future of breast cancer screening in UK?

discharge training for breast cancer patient

Mrs. Smith was diagnosed with Stage IV breast cancer 15 months ago. She underwent chemotherapy for...

Mrs. Smith was diagnosed with Stage IV breast cancer 15 months ago. She underwent chemotherapy for several months before a bilateral mastectomy was performed. She then completed six weeks of radiation therapy to the chest wall. Recently, she has been experiencing the inability to manipulate the tongue during chewing and swallowing, as well as difficulty in speech. Further investigation indicated that the left side of her tongue appeared to be paralyzed when asked to protrude her tongue past her lips....

Subjects