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In: Biology

If a non-competitive inhibitor binds to E, is it possible that it also binds to ES...

If a non-competitive inhibitor binds to E, is it possible that it also binds to ES in many cases? Group of answer choices

a. Yes

b. No

Solutions

Expert Solution

Yes, it is possible that a non-competitive inhibitor can also bind to ES in many cases.

Non-competitive inhibition is a type of enzyme inhibition where a inhibitor binds to the enzyme at other than its active site, thereby changes the shape of active site and thus declines its enzymal activity.

More precisely, a non-competitive inhibitor can bind to an enzyme whether or not it is bound with the substrate. The inhibitor shows the same affinity towards the both i.e., enzyme not bound with substrate and enzyme that is bound with substrate.

The reversible binding of the inhibitor to allosteric site of the enzyme and brings about possible changes in the active site if it has not bound with the substrate yet, thereby the substrate do not fit the active site thus declines its enzymal activity.

As if the enzyme has already bound with the substrate, in most of the cases the inhibitor can still bind with the enzyme and blocks the ability of the enzyme to undergo conformational changes thus declines its enzymal activity.

Non-competitive inhibition differs from that of competitive inhibition, where either of substrate or inhibitor can only bind to the enzyme. But here, the inhibitor can bind to the enzyme even if it is already bound with the substrate and vice versa.


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