Question

what are the pharmokinetics factor of fluoxetine

any two with explanation please

Answer 1

Fluoxetine is a antidepressant which is classifically comes under selective serotonin reuptake inhibitors (SSRI).uses in treatment of depression and OCD(obsessive compulsive disorders).

Pharmacokinetic factor of fluoxetine----

Pharmacokinetics is consistent of 1)drug absorption, 2)distribution, 3)metabolism, 4)excretion.

1)DRUG ABSORPTION-- drug is effective when taken in orally. This is beacuse of the lipophilic character of the drug .lipophilic drugs are easily absorbed.but the drug have to used in patient of hepatic dysfunction. Systemic Bioavailability of fluoxetine is happen after 6 to 8 hours of 15-50ng/mL

2)DRUG DISTRIBUTION-- the drug has a large volume of distribution and can accumulate is several body organs. Volume of distribution is nearly about to 22- 42 L/kg.

3) METABOLISM-- extensively metabolised by liver.active metabolites of fluoxetine is norfluoxetine due to the help of demethylation. In this case fluoxetine is the prodrug and the active form is norfluoxetine .the people who have reduced activity of CYP2D6 enzyme have seen metabolshing problem of this drug.

D) ELIMINATION or EXCRETION--the drug have a slow rate of elimination .mainly elimination is occured through urine . Elimination halflife of fluoxetine happen in 1 -4 days if it is used acute, and in chronic use it takes 3-9 days. Norfluoxetine has a elimination halflife of 4-15 days .... which leads to accumulation of drug .long drug elimination halflife indicates that there is a amount of drug present even if the drug is discontinued.