Question

can any one give me a good explanation for this two questions please?

How do long chain fatty acyl-CoA molecules regulate acetyl CoA carboxylase? please Explain also why this regulation makes sense.

Answer 1

Long chain fatty acyl CoA molecules regulates acrylic CoA carboxylase enzyme, as long acid fatty acid acyl CoA broken down into pyrophosphate, acyl CoA and AMP. Acetyl CoA carboxylase is regulated by three global factor i.e insulin epinephrine and glucagon. As insulin help in synthesis of fatty acid while glucagon and epinephrine has reverse effect. The amount of AMP , palmitoyl CoA and citrate also regulate acetyl CoA carboxylase or carboxylase . As I told u earlier that long fatty acyl CoA yield AMP the carboxylase is activated by phosphorylation and inactivated by dephosphorylation. AMP dependent protein kinase act on the serine residue in carboxylase enzyme which convert it into inactivate form. So AMP dependent protein kinase is activated by AMP and inhibited by ATP . It makes sense that if there is plenty of long fatty acyl CoA present , then there is no or less need of fatty acid synthesis