Please explain Eukaryotic Transcription in DETAIL (Pol I, Pol II, Pol III, and their respective factors...

Please explain Eukaryotic Transcription in DETAIL (Pol I, Pol II, Pol III, and their respective factors involved)

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Expert Solution

RNA polymerase I involved in synthesis of rRNA. Transcription yields 45S pre-rRNA which process to yield 28S, 18S, and 5.8S rRNAs. The promoter are recognised by UBF (upstream binding factor) and SL1 (selectivity factor 1) both recruit polymerase I to form an initiation complex. SL1 factor consists of TBP (transcription binding protein).

RNA polymerase II synthesis mRNA where it recognise sequence similar to TATAA box. Initially TFIID binds to TATA box, TFIID has TBP (TATA binding protein) which binds specifically to the TATAA consensus sequence. Then TBP binds TFIIB forms TBP-TFIB in the promoter region. Then RNA polymerase II binds with this complex with TFIIF.

RNA polymerase III synthesis tRNAs, 5S rRNA, and some of the small RNAs involved in splicing and protein transport. TFIIIA initiates assembly of a transcription complex through binding of DNA sequence in 5SrRNA promoter region. Then TFIIIC, TFIIIB, and the polymerase binds to that promoter region.

gladiator answered 1 year ago

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