How do the BCR and TCR receptors and the MHC protein receptors interact for the lymphocyte...

How do the BCR and TCR receptors and the MHC protein receptors interact for the lymphocyte identification of the antigen?

Expert Solution

The lymphocytes are of two types generally which are the T-helper cells(Th) and the Cytotoxic T lymphocytes(CTL). These lymphocytes identify the antigens when they are presented by antigens by the MHC receptors. The MHC class 1 receptors present the antigen to the CTL and the MHC class 2 receptors present the antigen to the Th cells. These MHC receptors interact with the T cell receptors (TCR) present on the T cells and hence help in the identification of the antigen by the T lymphocytes. These MHC molecules are present on the Antigen presenting cells(APC) such as macrophages, B cells and dendritic cells. The MHC class 2 receptor is present on these APC. The circulating pathogen is taken up these APCs and mainly by the B cells through the B cell receptor (BCR) and these pathogens are processed so that only a part of the pathogen is presented to the Th cells in the form of antigen. The MHC class 1 molecule are present on the Altered self cells(ASC) such as the NK cells which process the viral particles and present these antigens to the CTL through the class 1 MHC molecule.In this way all the receptors of the immune system help in the identification of the antigen by the lymphocyte.

If you have any query kindly comment before giving thumbs up. Thank you.

gladiator answered 2 years ago

Why do both the BCR and TCR receptors have a variable domain AND a constant domain?

1. What kind of cell is most likely to interact with a class I MHC protein...

1. What kind of cell is most likely to interact with a class I MHC protein on a cell surface? 2. The antibody-combining site binds to a part of the antigen that is complementary to the combining site. What is this portion of the antigen called? 3. Which T cell is most likely to be stimulated by the appearance of exogenous antigens presented by an antigen-presenting cell? 4. What properties of fibronectin and other similar molecules of the ECM allow...

This lymphocyte is responsible for killing infected cells following MHC I binding Group of answer choices...

This lymphocyte is responsible for killing infected cells following MHC I binding Group of answer choices Cytotoxic T cells Memory B cells Helper T cells Plasma B cells

What do both G protein-coupled receptors and tyrosine kinase receptors have in common? The binding site...

What do both G protein-coupled receptors and tyrosine kinase receptors have in common? The binding site for the signaling molecule is located on the outside of the cell. They both interact with G proteins. Binding of the signaling molecule forms a dimer. They both result in a phosphorylation cascade.

How do CD4 and CD8 coreceptors facilitate signaling through the TCR?

7. Describe the structure of the B-cell receptor (BCR). How is the BCR able to trigger...

7. Describe the structure of the B-cell receptor (BCR). How is the BCR able to trigger a signal transduction pathway when its cytoplasmic tail is only 3 amino acids in length? Outline BCR signal transduction from the point of antigen binding through the NF-κB pathway. What is the result of signal transduction events from the BCR?

Discuss the complexity of the TCR and two of its accessory partner receptors [PD-1, ox40] which...

Discuss the complexity of the TCR and two of its accessory partner receptors [PD-1, ox40] which appear to regulate the response mechanism within the cell. How do the partners impact the story?

The three main types of cell surface receptors are ion-channel-coupled receptors, G-protein-coupled receptors, and enzyme-couple receptors....

The three main types of cell surface receptors are ion-channel-coupled receptors, G-protein-coupled receptors, and enzyme-couple receptors. They are all capable of binding extracellular signaling molecules but differ in how they relay that signal across the membrane. How does each type of surface receptor relay signal?

Upon binding of a ligand, G-protein-coupled receptors do which of the following? Select one: a. The...

Upon binding of a ligand, G-protein-coupled receptors do which of the following? Select one: a. The G-protein exchanges a GDP for a GTP, and the alpha subunit detaches from the beta/gamma complex b. They dimerize, autophosphorylate, and trigger a cascade in intracellular signal transduction/phosphorylation c. They migrate to the nucleus to activate/repress specific genes d. They get internalized and start producing cAMP e. They induce apoptosis

How eukaryotic cells communicate? Describe the mechanism of G-coupling protein receptors with diagrams.

Question