In: Nursing
1. Multi-gene families are a consequence of which type of chromosomal mutation?
a) deletion
b) inversion
c) duplication
d) point
2. Which of the following is/are true?
a) There is typically a gain of genetic material in translocation.
b) In nonreciprocal intrachromosomal translocation a piece of the chromosome changes position to another chromosome
c) in nonreciprocal interchromosomal translocation a piece of chromosome is swapped with another chromosome
d) in reciprocal interchromosomal translocation two chromosomes exchange pieces
3. Linkage disequlibrium
a) typically yields a 9:3:3:1 ratio of alleles for loci at which the parents are heterozygous
b) can occur when genes are syntenic
c) shows indpendent assortment of genes
d) is concluded when a chi-square test (or other statistical test) deviates significantly from expectations derived from the Punnet square
4. Recombinants
a) are expected in linkage disequilibrium
b) have phenotypes like their parents or grandparents
c) are expected in independent assortment of genes
d) never occur when genes are linked
1. Option C. Multi gene family is the term used to include groups of genes from the same organism that encode proteins with similar sequences either over their full lengths or limited to a special domain.DNA duplication can generate gene pairs.
2. Option B is true . Option d is true if two chromosomes are non homologous .Translocation occurs when a piece of one chromosome breaks off and attaches to another chromosome.If no genetic material is gained or loss in the cell this type of re arrangement is described as balanced . If there is a gain or loss of genetic material the translocation is described as unbalanced.Intra chromosomal trans location involve the movement of of a chromosomal segment from one location in the chromosome to another.Reciprocal translocation occur when chromosomal segments are exchanged between two non homologous chromosomes. Non reciprocal translocations are a one way transfer of a chromosomal segment to another chromosome.
3.Option C.Linkage disequilibrium refers to the non random association of alleles at two or more loci in a general population.When alleles are in linkage disequilibrium,haplotypes do not occur at the expected frequency.
4. Option C. Recombinants or cells or organisms whose genetic complete results from recombination. The genetic material produced when segments of DNA from different sources are joined to recombinant DNA.