Your clinical instructor has asked you to prepare a talk on insulin glargine (Lantus) for your clinical group.

Your clinical instructor has asked you to prepare a talk on insulin glargine (Lantus) for your clinical group. What information will you include in your presentation?

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Expert Solution

1. Insulin glargine, marketed under the names Lantus.

2. It is a long-acting insulin analogue and is given once daily.

3. The glycine is substituted for asparagine at N21 (Asn21) and two arginines are added to the carboxy terminal of B chain.

4. The arginine is known to have an effect and shift the isoelectric point from a pH of 5.4 to 6.7. As a result, the molecule get more soluble at an acidic pH and less soluble at physiological pH. The glycine substitution prevents deamidation of the acid-sensitive asparagine at acidic pH.

5. Furthermore, the isoelectric shift also allows for the subcutaneous injection of a clear solution.

6. It is formulated at an acidic pH 4, where it is completely water-soluble.

7. After subcutaneous injection of the acidic solute, when a physiologic pH (approximately 7.4) is achieved the increase in pH causes the insulin to come out of solution.

gladiator answered 1 year ago

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