Question
In: Biology
Your clinical instructor has asked you to prepare a talk on insulin glargine (Lantus) for your clinical group.
Your clinical instructor has asked you to prepare a talk on insulin glargine (Lantus) for your clinical group. What information will you include in your presentation?
Solutions
Expert Solution
1. Insulin glargine, marketed under the names Lantus.
2. It is a long-acting insulin analogue and is given once daily.
3. The glycine is substituted for asparagine at N21 (Asn21) and two arginines are added to the carboxy terminal of B chain.
4. The arginine is known to have an effect and shift the isoelectric point from a pH of 5.4 to 6.7. As a result, the molecule get more soluble at an acidic pH and less soluble at physiological pH. The glycine substitution prevents deamidation of the acid-sensitive asparagine at acidic pH.
5. Furthermore, the isoelectric shift also allows for the subcutaneous injection of a clear solution.
6. It is formulated at an acidic pH 4, where it is completely water-soluble.
7. After subcutaneous injection of the acidic solute, when a physiologic pH (approximately 7.4) is achieved the increase in pH causes the insulin to come out of solution.
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