Can ACE (Angiotensin-converting enzyme) inhibitiors and angiotensin receptor blockers be used in hypertensive patients with renal insufficiency?

Can ACE (Angiotensin-converting enzyme) inhibitiors and angiotensin receptor blockers be used in hypertensive patients with renal insufficiency?

Expert Solution

ACE INHIBITORS CAN BE USED IN HYPERTENSIVE PATIENT WITH RENAL INSUFFICIENCY

provide renoprotective effects (nonblood pressure-dependent ) with antihypertensive therapy in patients with more advanced renal disease.. but Angiotensin-converting enzyme inhibitors (ACEIs) are contraindicated in patients with bilateral renal artery stenosis due to the risk of azotemia resulting from preferential efferent arteriolar vasodilation in the renal glomerulus due to inhibition of angiotensin II.

chronic renal failure can be prevent by ACE inhibitor

INHIBITION OF RENIN ANGIOTENSIN SYSTEM

1. sympathetic blocker decrease renin release

2. renin inhibitory peptides and renin specific antibodies block renin action-interfere with generation of AU from angiotensinogen

3. angiotensin converting enzymeprevent generation of active principle AII

4.AT 1 antagonisy block action of AII on target cell

5. Aldosterone antagonist block mineralocorticoid receptors

Nightingale answered 2 years ago

what is the actions of ACE (Angiotensin-converting-enzyme) inhibition in patients with renal artery stenosis?

Angiotensin-converting enzyme (ACE) inhibitor drug enalaprilat is used to treat hypertension and has poor oral bioavailability...

Angiotensin-converting enzyme (ACE) inhibitor drug enalaprilat is used to treat hypertension and has poor oral bioavailability as well as a short half-life. What functional groups and properties of the drug may be responsible for these drawbacks and what can be done to modify the structure to improve both oral bioavailability and half-life?

Explain the extrinsic regulation of GFR. Explain how an angiotensin converting enzyme inhibitor (ACE inhibitor) such...

Explain the extrinsic regulation of GFR. Explain how an angiotensin converting enzyme inhibitor (ACE inhibitor) such as captopril would be effective as an antihypertensive.nnn

Your company, DrugsRUs, has developed a generic angiotensin-converting-enzyme inhibitor, Vasotec, as a pharmaceutical drug used primarily...

Your company, DrugsRUs, has developed a generic angiotensin-converting-enzyme inhibitor, Vasotec, as a pharmaceutical drug used primarily for the treatment of hypertension and congestive heart failure. You are leading the regulatory strategy team and have been asked to describe the path to approval comparing introduction in the US versus Brasil. Please discuss the following: (1) Which agency or agencies will be responsible for approving/reviewing your Vastec drug: (a) before commercial introduction, and (b) after approval for commercialization/sale within the US., and...

1) What will happen if Angiotensin Converting Enzyme production is increased? Choose whether they increase or...

1) What will happen if Angiotensin Converting Enzyme production is increased? Choose whether they increase or decrease: a) Blood Volume b) MAP c) GFR d) Vasopressin release - - - 2) Will this cause a positive or negative sodium balance?

What would change if the lungs did not produce Angiotensin-Converting Enzyme? What is/are the differences between...

What would change if the lungs did not produce Angiotensin-Converting Enzyme? What is/are the differences between the two sphincters of the urinary bladder? (Can you make a chart for this one :) ) Thanks so much <3

Enalaprilat is a competitive inhibitor of the angiotensin-converting enzyme (ACEACE), which cleaves the blood-pressure regulating peptide...

Enalaprilat is a competitive inhibitor of the angiotensin-converting enzyme (ACEACE), which cleaves the blood-pressure regulating peptide angiotensin I. ACEACE has a KM=52KM=52 μMμM for angiotensin I, which is present in plasma at a concentration of 78 μMμM. When enalaprilat is present at 2.8 nMnM, the activity of ACE in plasma is 13 %% of its uninhibited activity. What is the value of KIKI for enalaprilat?

Why can steatorrhea be observed in patients with pancreatic insufficiency and patients with ileal resection (removal)?...

Why can steatorrhea be observed in patients with pancreatic insufficiency and patients with ileal resection (removal)? (compare their causes and consequences)

A. How can you manage nutritionally a patient suffered renal failure? The patient is male, hypertensive,...

A. How can you manage nutritionally a patient suffered renal failure? The patient is male, hypertensive, diabetic type-2, obese, and aged 58 years. The patient has been advised to postpone the renal dialysis (Weight is 110 kg, height is 180 cm). 1. What are the requirements of macronutrients? 2. What are the requirements of water? What about hot weather? 3. What are the required micronutrients? 4. If anemia and osteoporosis how can you manage the complications? 5. If patient has...

Drugs are often used for reducing the blood pressure of hypertensive patients (those with high blood...

Drugs are often used for reducing the blood pressure of hypertensive patients (those with high blood pressure). An experiment was run to investigate the effect of Drug (A or B) and Dose Level (Low or High) on the reduction in blood pressure. The experiment was conducted separately for the 36 patients who had mild hypertension and the 24 patients who had severe hypertension as the researcher suspected that results may differ for the two groups. For this design, there are:

Question