what is the actions of ACE (Angiotensin-converting-enzyme) inhibition in patients with renal artery stenosis?

Expert Solution

Nightingale answered 2 years ago

Can ACE (Angiotensin-converting enzyme) inhibitiors and angiotensin receptor blockers be used in hypertensive patients with renal insufficiency?

If a patient has renal artery stenosis (narrowing of the renal artery) due to atherosclerosis, what...

If a patient has renal artery stenosis (narrowing of the renal artery) due to atherosclerosis, what is the impact of this on GFR? Specifically, be sure to discuss the impact on the afferent and/or efferent arterioles as well as effects on hydrostatic and/or oncotic pressure.

Explain the extrinsic regulation of GFR. Explain how an angiotensin converting enzyme inhibitor (ACE inhibitor) such...

Explain the extrinsic regulation of GFR. Explain how an angiotensin converting enzyme inhibitor (ACE inhibitor) such as captopril would be effective as an antihypertensive.nnn

Angiotensin-converting enzyme (ACE) inhibitor drug enalaprilat is used to treat hypertension and has poor oral bioavailability...

Angiotensin-converting enzyme (ACE) inhibitor drug enalaprilat is used to treat hypertension and has poor oral bioavailability as well as a short half-life. What functional groups and properties of the drug may be responsible for these drawbacks and what can be done to modify the structure to improve both oral bioavailability and half-life?

1) What will happen if Angiotensin Converting Enzyme production is increased? Choose whether they increase or...

1) What will happen if Angiotensin Converting Enzyme production is increased? Choose whether they increase or decrease: a) Blood Volume b) MAP c) GFR d) Vasopressin release - - - 2) Will this cause a positive or negative sodium balance?

What would change if the lungs did not produce Angiotensin-Converting Enzyme? What is/are the differences between...

What would change if the lungs did not produce Angiotensin-Converting Enzyme? What is/are the differences between the two sphincters of the urinary bladder? (Can you make a chart for this one :) ) Thanks so much <3

Enalaprilat is a competitive inhibitor of the angiotensin-converting enzyme (ACEACE), which cleaves the blood-pressure regulating peptide...

Enalaprilat is a competitive inhibitor of the angiotensin-converting enzyme (ACEACE), which cleaves the blood-pressure regulating peptide angiotensin I. ACEACE has a KM=52KM=52 μMμM for angiotensin I, which is present in plasma at a concentration of 78 μMμM. When enalaprilat is present at 2.8 nMnM, the activity of ACE in plasma is 13 %% of its uninhibited activity. What is the value of KIKI for enalaprilat?

Your company, DrugsRUs, has developed a generic angiotensin-converting-enzyme inhibitor, Vasotec, as a pharmaceutical drug used primarily...

Your company, DrugsRUs, has developed a generic angiotensin-converting-enzyme inhibitor, Vasotec, as a pharmaceutical drug used primarily for the treatment of hypertension and congestive heart failure. You are leading the regulatory strategy team and have been asked to describe the path to approval comparing introduction in the US versus Brasil. Please discuss the following: (1) Which agency or agencies will be responsible for approving/reviewing your Vastec drug: (a) before commercial introduction, and (b) after approval for commercialization/sale within the US., and...

Decreased blood flow through the renal artery stimulates the release of renin into the blood. What...

Decreased blood flow through the renal artery stimulates the release of renin into the blood. What happens next? Describe the process until it has influenced renal function.

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