Question

hey.

so I need to understand what each of the following Cytokines do:

TNF? , TNF?, TNF ?, IL-3 (G-CSF and GM-CSF), IL-7 (so I undesrtand there is also something similiar like in 3 with CSF?, does he decide to what lymphocyte will be produced? if not who does that and whats his function), IL-4, IL-5, IL-6, IL-17, IL-2, IL-12, IL-1, IL-8 (didn't get what they mean by does chemotaxis), IL-10 and IL-13.

ok so this is the first course of immunology so I need these IL's functions related with only these subjects so I don't draft from the main subject:

Inflamation (acute and chronic)

anything relating production, activation, proliferation and inhibitions of white cells.

cancer

auto immunity

alergic reaction

[if possible please type the answer in a computer]

thanks allot!

Answer 1

1. TNF- It is important for the normal embryogenic development, in apoptosis, in growth & differenciation, in induction od CAMs (Cell Adhesion Molecules), in inflamation, etc.

2. TNF- It is known to possess cyto-toxic activity against tumors, it mediates inflammation and regulates various immune responses.

3. TNF- It is important to produce an immune response gainst varios pasasitic, protozoan and bacterial infections, in causes the activation of macrophages, it induces the expression of MHC-II molecules, it promotes the activity of NK cells, it enhances the lysosomal activity in macrophages, it increases the antigen presentation process, etc.

4. IL-3: It helps in differentiation of hemopoetic stem cells, it helps in growth and differentiation of T-cells and these activated T-cells will promote autocrine and paracrine signalling.

5. IL-4: It helps in differentiation of naive T_H cells, in stimulating the proliferation of activated B and T cells, in differentiation of B-cells into plasma cells which can produce antibodies, regulates humoral and cell mediated immune response, in class switching, etc.

6. IL-5: It promotes the growth of B-cells, it enhances the secretion of antibodies formed from plasma cells and it helps in mediating the activation of eosinophils.

7. IL-6: It has an ability to cross the blood-brain barrier and cause stimulate the synthesis of prostaglandins, it is important for the growth of hybridoma, it promotes the growth of B-cells and works antagonastically to T-reg cells and it enhances the neutrophills production in bone marrow.

8. IL-17: It induces activation of other signalling molecules, it is associated with the allergic reactions, it induces the production of cytokines such as INF, TNFs and prostaglandins, it's release can attract more neutrophils but not eosinophils.

9. IL-2: It directly affects the T-cells so it plays crucial functionin tolerance and immunity, it helps in promoting differentiation of immature T-cells into T-reg cells so that it can prevent the auto-immunity from happening, it is important part of adaptive immunity.

10. IL-12: It differntiates naive T-cells into Th1 cells, It produces INF gamma and TNF alpha, it enhances the activity of NK cells, it blocks the process of angiogenesis, etc.

11. IL-1: It regulates hemopoesis and inflammation, it causes increase in neutrophils population, helps in proliferation of fibroblasts, etc.

12. IL-8: I act as chemotactic factor for the neutrophils so hat they can be accumulated at the site of injury, stimulation of phagocytosis, promotes angiogenesis, involved in innate immune resonses.

13. IL-10: It is involved in inflammation and immunoregulation, it decreases the effect of Th1 cells, regulates the JAK-STAT pathway, it helps in enhancement of B-cell production and antibody secretion and inhibits the production of TNF and INF.

14. IL-13: It possess anti-inflammatory properties, helps in induction of change in hemopoetic cells, it enhances the production and secretion of IgE antibody, etc.