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Background on cell division in plants: Why is cell division a regulated process? What is known...

Background on cell division in plants: Why is cell division a regulated process? What is known about division plane orientation in plants? Please explain in detail! I'll upvote

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Regulation of the cell division involves processes crucial to the survival of a cell, including the detection and repair of genetic damage as well as the prevention of uncontrolled cell division. The molecular events that control the cell division are ordered and directional; that is, each process occurs in a sequential fashion and it is impossible to "reverse" the cycle.

Cell cycle regulation is crucial for proper cellular homeostasis. Communication between or within a cell is done through cell signaling and a change in the activity of the cell is sent as a signal that may trigger a cascade of reaction for the body to respond accordingly.

Cell division orientation is the direction along which the new daughter cells are formed. Cell division orientation is important for morphogenesis, cell fate and tissue homeostasis. Abnormalities in the cell division orientation leads to the malformations during development and cancerous tissues. Factors that influence cell division orientation are cell shape,anisotropic localization of specific proteins and mechanical tensions.

Implication for morphogenesis

Cell division orientation is one of the mechanisms that shapes tissue during development and morphogenesis. Along with cell shape changes, cell rearrangements, apoptosis and growth, oriented cell division modifies the geometry and topology of live tissue in order to create new organs and shape the organisms. Reproducible patterns of oriented cell divisions were described during morphogenesis of Drosophila embryos, Arabidopsis thaliana embryos,Drosophila pupa, zebrafish embryos and mouse early embryos. Oriented cell divisions contribute to the tissue elongation and the release of mechanical stress. While in the first case oriented cell division acts as active contributor to the morphogenesis, the latter case is a passive response to the external mechanical tensions.

Implication for tissue homeostasis

In several tissues, such as columnar epithelium, the cells divide along the plane of the epithelium. Such divisions insert new formed cells in the epithelium layer. The disregulation of the orientation of cell divisions result in the creation of the cell out of epithelium and is observed at the initial stages of cancer.

Regulation

Cartoon of the dividing epithelium cell surrounded by epithelium tissue. Spindle apparatus rotates inside the cell. The rotation is a result of astral microtubules pulling towards tri-cellular-junctions (TCJ), signaling centers localized at the regions where three cells meet.

More than a century ago Oskar Hertwig proposed that the cell division orientation is determined by the shape of the cell (1884), known as Hertwig rule. In the epithelium the cells 'reads' its shape through the specific cell junction called tricellular junctions (TCJ). TCJ provide mechanical and geometrical clues for the spindle apparatus to ensure that cell divide along its long axis. Several factors could regulate cell shape and therefore orientation of cell division. Among these factors is the anisotropic mechanical stress. This stress could be the result of the external mechanical deformation of generated intracellularly by non-isotropic localization of specific proteins.


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